Follicular Thyroid cancer and new driver mutations
Follicular Thyroid cancer and new driver mutations New developments on thyroid cancer front this week. A research group from South Korea published an article on the transcriptional and mutational landscape of follicular (FTC) and papillary thyroid cancers (PTC). The reason this is big news is that this is the first time when a comprehensive data is being published on FTCs. Comprehensive data on PTC already exist as it was published in 2014 . I am not going to discuss the whole of the article but there was few interesting points which caught the eye. One of which was that the authors proposed new driver mutations for thyroid cancer, of the many two of them are EZH1 (a member of polycomb group protein complex) and LKB1. The interesting part came from another group in Italy who published a paper in JCI about role of EZH1 in development of thyroid adenomas. The paper describes the role of cAMP signaling from TSHR mutations which when combined with EHZ1 mutations lead t...